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Ovarian Cancer

Approximately one of every seventy women in the United States will contract ovarian cancer at some point in her life. The risk of developing this form of cancer increases with early age at first menstruation, late menopause, and no pregnancies. All of these conditions increase the chances that estrogen, the primary female hormone, will stimulate the development of ovarian cancer. High-fat diets, the use of talcum powder in the underwear, and exposure to asbestos or radiation have also been associated with an increased risk for ovarian cancer. Heredity also plays a role in this disorder.

The symptoms of ovarian cancer are abdominal swelling, masses in the abdomen, bleeding, lower back pain, and urinary difficulties. Benign ovarian cysts can also cause these symptoms. (Sudden, sharp, and severe pain is usually caused by an ovarian cyst.) Because the symptoms of ovarian cancer overlap with several other conditions, this cancer is difficult to detect early and is frequently diagnosed only at an advanced stage.

A firm diagnosis is made by biopsy, although a number of other tests may be performed. Ovarian cancer is classified into stages I through IV by the extent of spread and by the type of cell from which it originated. It most often spreads to nearby organs within the abdomen, and then to the liver, lungs, or bones.

A number of conventional treatments are used for ovarian cancer. About 50 percent of ovarian cancers involve a defect in the "cancer-patrol" gene p53, a gene that is also important in controlling most kinds of cancer occurring in the breast, cervix, colon, lungs, and prostate, and in all strains of small-cell lung cancer. Herbal treatment is most likely to be helpful in these cases. Always use herbal medicine as part of a medically directed overall treatment plan.

Supplements and herbs

  • Astragalus capsules. Take 500-1,000 mg 3 times daily.
    Increases production of immune-system chemical interleukin-2 (IL -2), which fights human papilloma virus (HPV). Activates gene pS3.
  • Espinheira santa tincture. Take as directed on the label.
    Slows growth of ovarian tumors.
  • Green tea catechin extract. Take 250-500 mg daily.
    Deactivates plasmin, which helps tumors spread.
  • Mistletoe loranthus or mulberry mistletoe. Use only under professional supervision.
    Greatly increases survival time in advanced ovarian cancer.
  • PSK tablets. Take 6,000 mg daily.
    Simulates production of immune agent IL -2.
  • Quercetin tablets. Take 125-250 mg 3 times daily, between meals.
    Stops chemical signals that give ovarian cancer cells a growth advantage over healthy cells.
    Do not take quercetin with cyclosporine (Neoral, Sandimunne) or nifedipine (Procardia).
  • Soy isoflavone concentrate tablets. Take 3,000 mg daily.
    Interrupts multiplication of ovarian cancer cells.
  • Turmeric curcumin tablets. Take 250-500 mg twice daily, between meals.
    Activates gene p53. Prevents inflammation.

HERBS TO AVOID - People who have ovarian cancer should avoid the following herbs: cordyceps, dan shen, fennel, licorice, and peony.

What else you can do

  • Use both quercetin and soy isoflavones. Studies at the Indiana University School of Medicine have found that quercetin and genistein, a key soy isoflavone, enhance each other's effects.
  • Take 200 micrograms of selenium daily. Selenium supplements are especially useful for women with ovarian cancer who are undergoing multi-medication chemotherapy.
  • Avoid weight-loss diets and fasts. Although certain kinds of fat restriction reduce the risk of developing ovarian cancer, calorie restriction after the disease has developed may accelerate the disorder's progress.
  • Surgery is the first line of treatment for ovarian cancer. In addition to the ovary, the uterus and fallopian tubes also may be removed, as may the membrane that lines the abdomen. After surgery, physicians give combinations of chemotherapy, immunotherapy, and radiation therapy.
  • Doctors can do a preliminary test for ovarian cancer, using either ultrasound or a cancer marker test called CA-125, without resorting to surgery. It has also been found that women with early-stage ovarian cancer tend to have elevated levels of a compound known as lysophosphatidic acid (LPA) in their blood. Research is underway on the possibility that testing for LPA levels might provide a way to screen for this disease and, hopefully, detect it in earlier stages.
  • The dietary factors that contribute to the risk of ovarian cancer are more specific than those for other cancers. Vegetable fiber decreases risk by approximately 60 percent for each 10-gram increase in the average daily amount of vegetable fiber consumed (about that found in five to seven servings of vegetables). Each increase in daily saturated fat consumption of 10 grams (about 100 calories) increases risk of developing ovarian cancer approximately 20 percent; consumption of unsaturated fats neither increases nor decreases risk. Cholesterol from eggs, but not from other sources, increases risk of developing ovarian cancer approximately 40 percent for each 100-milligram increase in average daily consumption (about half of an egg). (Increased risk is also associated with total cholesterol levels over 100 mg/ dl.) In addition, habitual consumption of more than two alcoholic drinks per day is associated with increased risk.
  • Adequate levels of selenium not only support treatment for ovarian cancer but also reduce the risk of developing this disease. Low levels of selenium have been associated with a greater risk of ovarian cancer. A daily dosage of between 150 and 200 micrograms is enough.

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