Nicotinamide Adenine Dinucleotide
( NADH )

The complex dinucleotide compound NADH is one of the most important energy storing molecules found in all cells. It is an active coenzyme, and is partly derived from the vitamin B3 - also known as niacin. This coenzyme has a vital role in all the energy generating transfer reactions that power the living cell. The production of many vital neurotransmitters is boosted in the brain when the concentration of nicotinamide adenine dinucleotide (NADH) increases in brain tissues.

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Two types of studies have shown the relative usefulness of supplementing nicotinamide adenine dinucleotide (NADH) to people affected by Parkinson's disease, in large scale uncontrolled studies, all the subjects showed significant reduction in physical disability and could manage with a reduced amount of medication, after injections of nicotinamide adenine dinucleotide (NADH). This is in stark contrast to the results obtained from small controlled and short terms trials using NADH, patients reported no significant effects in this studies. The use of oral supplements of  nicotinamide adenine dinucleotide (NADH) also led to greatly improved mental functioning in people down with Alzheimer's disease in a small uncontrolled study. People affected by chronic clinical depression or long term chronic fatigue syndrome can also benefit from supplemental nicotinamide adenine dinucleotide (NADH) according to preliminary studies conducted in some laboratories. Independent and laboratory verification is needed to confirm the truth behind these promising results, as this data comes from research conducted by the inventor of the oral NADH supplement.

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As far as metabolism is concerned, nicotinamide adenine dinucleotide or NADH has several functions. This complex compound assists enzymes in their activities all over the body and has a crucial role in generating energy. NADH also facilitates in dopamine production. It may be noted that dopamine is actually a neurotransmitter carrying signals from one nerve to another. The findings of a study revealed that NADH augments the function of the mind significantly in individuals enduring jet lag.

It may be noted that nicotinamide adenine dinucleotide is basically a molecule that functions in the form of a coenzyme. Coenzymes are those that assist other enzymes function in chemical reactions and several vital chemical reactions within our body make use of NADH. However, the manner in which NADH supplements precisely work in different conditions it is yet to be ascertained. This is of specific interest since our body is capable of producing NADH itself. It is believed that NADH may possibly possess antioxidant actions and this is likely to hypothetically be one of the methods for this molecule to work for an assortment of health conditions.

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Nicotinamide adenine dinucleotide (NADH) supplements can be used by people struggling with clinical depression, those affected by Alzheimer's disease and Parkinson's disease as well as people with long term chronic fatigue syndrome. The beneficial effects of nicotinamide adenine dinucleotide (NADH) will best be felt after supplementation goes on for some period of time. Each patient may respond to the supplement in a different way.

Some condition specific uses of NADH are discussed below in brief.

Nicotinamide adenine dinucleotide (NADH) facilitates in providing relief from a health condition known as chronic fatigue syndrome. The findings of a new research that was endorsed by the Food and Drug Administration (FDA) of the United States, which has discovered that the oral variety of NADH was useful for a small set of patients enduring chronic fatigue syndrome. About 31 per cent of patients, who took part in the study, said that while taking NADH, they were feeling further energetic and more alert mentally. Just 8 per cent of the patients who were given placebo confirmed of experiencing this kind of improvement.

NADH works to improve common exhaustion, in addition to fatigue related to fibromyalgia (a health problem distinguished by fatigue and muscle aches). Since NADH augments vigour in the cells, a number of researchers contemplate that this complex molecule may well perk up energy in individuals suffering from fibromyalgia. In addition, NADH is also likely to hold off common, routine exhaustion by facilitating the supply of energy to the muscle cells.

It may be noted that depression is often attributed to imbalances in the chemicals present in our brain. As NADH promotes the making of several vital chemical, including neurotransmitters, this complex molecule may perhaps have a function in easing the symptoms of depression.

There are some initial confirmations that using NADH supplements may possibly elevate the dopamine (a neurotransmitter) levels. In effect, dopamine is an amalgam that is vital for inhibiting the physical signs of Parkinson's disease as well as providing respite from depression, which frequently accompanies this condition. It may be specifically mentioned that people enduring Parkinson's disease usually have a declining supply of dopamine.

A number of researches undertaken in the European countries with NADH have found that this complex molecule has shown the potential to be effective in curing people suffering from Alzheimer's disease. However, till date, scientists are yet to undertake any properly planned double-blind trials controlled by placebo to establish this consequence. According to the initial findings of one study, a very small set of patients enduring Alzheimer's disease who took NADH demonstrated an improvement in cognitive dysfunction.

Sources of NADH

The nicotinamide adenine dinucleotide (NADH) is primarily found in the foods like fish, all poultry, and cattle, and in yeast containing food products. Though it may be a little hard to find, NADH supplements can be found in some health food stores.

Nevertheless, it is yet to be ascertained whether the body is able to effectively take up or make use of the NADH obtained from the above mentioned sources. In addition to the sources mentioned above, NADH is also available in the form of a dietary supplement.

Deficiencies and susceptibility

A deficiency of nicotinamide adenine dinucleotide (NADH) can only happen if the diet is deficient in vitamin B3, and except in long term alcoholics, deficiencies of the vitamin B3 is almost unknown in the modern western world.

Usual dosage

Dosage requirements differ and clinical researchers typically administer ten mg of the supplement daily to their subjects in tests. Supplements of NADH must be consumed on an empty stomach and that too, only with water to wash it down.

From the chemical point of view, it seems that NADH or nicotinamide adenine dinucleotide is an unstable molecule, which molders very fast. This is the primary reason why scientists have developed new modus operandi to make the NADH that is marketed in tablet form stable.

Side effects and cautions

Side effects as a result of supplementing with nicotinamide adenine dinucleotide (NADH) have not been reported in clinical studies that were conducted using oral or intravenous administration of NADH. The tested subjects did not report any side effects even after they were evaluated for a full year.

Thus far, researchers have not evaluated the safety as well as effectiveness of the NADH in pregnant women and nursing mothers. By themselves, this group of women ought to stay away from using NADH supplements if not they have been directed by their physician or any professional healthcare practitioner.


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