The plant commonly called by names such as the Chinese thorough wax or the bupleurum is an herb native to parts of East Asia.
The bupleurum is a perennial herb, which tends to grow in wild profuse patches along the sunny sides of sedge thickets in many areas of East Asia.
The herb is characterized by the presence of many broad linear to lanceolate shaped leaves arranged in an alternative array along the stem.
The shape of the leaves are peculiar, with acuminate shape apexes having a gradually tapering base, morphologically the leaves are also characterized by having parallel running veins which run seven to nine inches thick and the leaf margins are intact without any peculiar edges.
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The herb also bears a lot of small and golden colored flowers during the autumn, these tend to be placed at terminal or axillary positions and develop as compound umbellate inflorescences on the plant body.
An elliptical or flat shape characterizes the seed capsule borne on the herb following the floral bloom.
The bupleurum initially appears in the literature of ancient China as one of China's so called "harmony" herbs and is recorded as a distinct plant in herbal treatise dating to the first century BC.
The Chinese "harmony" herbs are a class of plants believed to be involved in maintaining the internal energies within the body of a person and aiding in the maintenance of a balance among all the different organs inside the body.
The herb is traditionally used as an herbal tonic remedy to bring about improved functioning of the liver; it has a strengthening action on the performance of the digestive tract and is believed to aid the body by rushing blood to the surface of the body in patients affected by circulatory problems.
The beneficial effects traditionally attributed to the herb, specifically its protective action on the liver has been confirmed in the course of recent researches carried out in Japan. Thus the traditional beneficial effects attributed to the herb do have a basis in fact.
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Roots.
Ancient Chinese medical texts dating back to two millennia mention the use of the bupleurum as an herbal tonic for the treatment and strengthening of the liver.
As an herbal tonic, the bupleurum is traditionally held in China, as possessing a tonic effect over the spleen and the stomach and is also thought to strengthen the liver qi.
The situation of "disharmony" between the liver and the spleen is thought to be alleviated by remedies made from the bupleurum in the Chinese medical lore, symptoms such as the presence of acute abdominal pain, bloating in the stomach, the appearance of nausea, and persistent indigestion are all linked to this "disharmony" between the spleen and the liver.
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In the Chinese system of medicine, a physically weakened liver or a poorly functioning liver is believed to be ideally and effectively treatable using the bupleurum herb alone, this is a property the herb shares with other more common herbs like the milk thistle and all the species of the plant genus Glycyrrhiza - the gan cao herb and licorice herb are suitable examples of this genera.
Liver conditions and diseases are easily dealt with due to the strong anti-inflammatory action possessed by the herb; this property of the bupleurum is believed to be a major contributory factor in its ability to heal liver disorders.
The treatment of a persistent fever is also normally undertaken in Chinese medicine by giving the patient a bupleurum based remedy, particularly when the fever is accompanied by the presence of a bitter taste in the mouth of the patient, and if there are other tell tale symptoms such as constant irritability, accompanied either by vomiting and abdominal pain, or by spells of dizziness and sudden vertigo at unexpected moments.
East Asian doctors and particularly Japanese medical professionals have started to use the bupleurum in the treatment of patients, the benefits accruing to the liver from the use of the herb is so well supported in the traditional lore and has been so well confirmed in scientific research that many conventional Japanese doctors practicing Western medicine may treat patients affected by liver problems by prescribing the extract of the bupleurum.
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Root extracts have an inhibitory effect on pro-inflammatory factors. Saikosaponins are responsible for this.
The extract has apoptotic properties (acceleration of cell death) and anti-proliferative properties (inhibition of cell development).
It is active in the case of lung, liver, breast and glioblastoma multiforme cancer cells. In addition, in the case of breast cancer, it weakens the resistance of cancer cells to the drug doxorubicin.
This raw material has a protective effect, activating macrophages that engulf microorganisms by phagocytosis. It also stimulates the production of interleukins - cytokines that transmit information to the immune system.
Saikosaponins contained in the root extract have an antiviral effect on coronaviruses and inhibit their activity. These compounds also demonstrate activity against the HBV virus, inhibiting its replication.
Ethanol extracts from bupleurum roots have a bacteriostatic effect on H. pylori and increase resistance to Gram-positive and Gram-negative bacteria.
Saikosaponins and polysaccharides contained in bupleurum demonstrate hepatoprotective activity, reduce the effects of toxins acting on the liver and inhibit the deterioration of the liver in cirrhosis of this organ.
They also have antioxidant effects and reduce the deposition of collagen in the liver.
Studies have shown a positive effect of taking extracts from the root of bupleurum on Alzheimer's disease. Saikosaponins demonstrate a modulating effect on the action of proteins that cause this disease.
The treatment of more serious disease such as bone cancer might also be possible by using extracts of the bupleurum.
Some of the other disorders and conditions in which remedies made from the bupleurum have at times been proven to be effective include the treatment of hemorrhoids and the treatment of prolapsed tissues in the pelvic region, the herb has also been used in the treatment of uterus prolapse in affected women.
The bupleurum herb is a native species of China and other parts of East Asia, these days, extensive cultivation of the plant for herbal purposes is carried out in central and eastern china - mainly to meet the demand of the Chinese medical market.
Some other areas of East Asia as well as Europe also have population of bupleurum, though the herb is not cultivated in a large scale.
Abundant sunlight and well drained soils are ideal growing conditions for the bupleurum; during the spring, the plant is propagated from seed, though propagation of bupleurum by the root division technique is also carried out in the autumn months.
Depending on the time of propagation, harvesting and collection of bupleurum root is carried out during the spring and the autumn - in all areas where the herb is cultivated. Roots are then stored and processed for the herbal market.
The presence of active compounds called saikosides in the bupleurum was reveled in the researches carried out in Japan starting in the 1960s, the research on the bupleurum genus continues to this day and the medical value of the saikosides in the herb have been confirmed.
These organic active compounds are capable of boosting liver function and also seem to be able to protect the liver from metabolic toxicity of all types, favorable effects have been induced even in the livers of individuals suffering from immune system disorders and the active saikosides seem to have a general detoxification effect.
The effectiveness of the bupleurum in the treatment of hepatitis and other chronic liver conditions was also confirmed in subsequent clinical trials conducted during the 1980s in Japan - these human trials were conducted to check the beneficial effects of the saikosides on human subjects.
The overall synthesis of corticosteroids in the body is also increased by saikosides, at the same time these compounds also boost the anti-inflammatory effect of the steroids, enabling a stiffer immune system to develop in patients.
Bupleurum contains:
Products obtained from bupleurum should not be taken during pregnancy or breastfeeding. Special caution should be exercised when using it if the patient suffers from:
Bupleurum may cause the following side effects:
It may also cause breathing problems.