Vitamin B3 ( Niacin )

One of the major roles of the B complex vitamin's niacin is in the regulation of cellular respiration and in promoting the proper utilization of all the major nutrients at the cellular level. At least forty different bio-chemical reactions have been identified as being controlled by two co-enzymes, both of which require niacin for proper functioning. There is no doubt that the vitamin niacin is among the most important bio-chemical factors in maintaining optimum health levels in the human body.

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One major role of the vitamin B3 is as a mild vasodilator - an action that results in the widening of the diameter of blood vessels leading to a greater blood flow along the arterial or venous systems. Vitamin B3 given at sufficiently high doses also induced a peculiar reaction in the body known as the "niacin flush", besides reducing high blood cholesterol levels - during this reaction termed the "niacin flush," the temperature of the skin increases, there is reddening of the face, followed by a temporary drop in blood pressure. Spells of dizziness may also affect the person.

The mobilization of fat reserves from the tissues is also inhibited by high doses of niacin. Niacin's inhibition of fat store mobilization has health implications for people on a diet, athletes and long term alcoholics, as well as people affected by heart disease. The opposite effect is induced by alcohol; this compound actively mobilizes fat from the tissues putting most of the fat so mobilized into the blood stream, the increased blood fats all go to the liver in the end. The livers of animals given extremely high doses of niacin were studied following the administration of alcohol - the supplements of niacin prevented the accumulation of fat in the liver of the tested animals. The liver is without a doubt protected by the actions of niacin, in fact this is a protective action afforded by many of the other B vitamins. However, the practicality of such high doses of niacin as used in the experiment is questionable and will not work on human beings, as high doses of the vitamin can induce other symptoms which may be less than beneficial to the person. The alcoholic consumption of a person may be too high, if such high doses of niacin are necessary to protect the liver from the effects of alcohol - in addition, alcoholism has other effects on the body which cannot be solved by vitamin supplements at any dose. At the same time, in the tested animals, the high doses of niacin actually kept the alcohol in the blood for a longer time than normal. Thus, there is a distinct trade off, and exposing the other organs and tissues to high levels of alcohol for longer period of time may not be worth the little protection the liver gains.

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Animals that were given large doses of niacin - as niacinamide, another form of niacin - experienced an increase in the amount of rapid eye movement (REM) sleep - REM sleep is the most restful state of sleep in mammals. But such high dosages are all but impractical for humans and the effect on have little relevance to the correction of sleeping problems in otherwise healthy individuals. This beneficial effect of niacin on sleep disorders may however, have strong implications in the treatment of people suffering from some form of mental illness.

Pellagra is the oldest known deficiency syndrome related to a deficiency of niacin in the diet. Each cell in the human body may be affected by a deficiency of niacin, as niacin's plays vital roles even in the most basic of biochemical reactions at the cellular level. Pellagra mainly affects three major "target" organs - these are the skin, the nervous system and any area along the gastrointestinal tract. Research indicates that a prolonged deficiency of niacin can bring about a more or less permanent state of dependency for the vitamin or cause a greatly increased requirement for the vitamin in the diet.

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Pellagra caused by niacin deficiency results in the "3-Ds" symptoms, the D standing for each individual symptom. These are dermatitis, diarrhea and dementia. Symptoms of dermatitis induced by pellagra can partly resemble the symptoms of other B vitamin deficiencies - the person has a swollen and bluish tongue coupled with inflammation in the mouth and around the lips. These symptoms of pellagra are the least and smallest manifestations affecting the skin of the person. The person's skin can turn a deep red color, infected and affected by blisters and fissured, scaly or hardened. Such symptomatic skin lesions normally appear on affected areas of the skin that are normally exposed to strong sunlight or to physical trauma. The most common areas that are affected include the elbows and the knees, the skin on the back of the neck and the hands as well as the skin on the forearms. There may be soreness in the mucous membranes of the mouth, this area can be ulcerated and eventually start to hemorrhage as the ulcers cracks up.

In a similar fashion, such symptoms are also seen in the mucous membranes along the gastrointestinal tract. Some other symptoms that can result include a reduction of the digestive secretions along with a persistent burning sensation and gastric discomfort, this is followed by abdominal distention, persistent flatulence and an occasional bout of vomiting that gives way to severe diarrhea.

The nervous system is affected similar with symptoms which can cause a lot of distress to the affected person. Physical symptoms that initially appear include mild but persistent mental anxiety, strong and constant apprehension, physical and mental fatigue, a sudden loss of appetite, hypersensitive skin, problems with digestion, persistent headache and insomnia, mental tension and alternating bouts of depression and hyperactivity. Some of these symptoms worsen over time and can progress to general irritability, prolonged emotional instability and different psychotic symptoms can come about including hallucinations, mental confusion, disorientation and paranoia, delirium and mania, impaired vision and perception, a hypersensitivity to light, the development of a hyper acute sense of smell, the dulling of the sense of taste, and severe and long term depression.

Niacin deficiency can also induce the manifestation of a group of symptoms quite distinct from the symptoms of pellagra. The person can be affected by some of the less severe symptoms of dermatitis, they can experience a strange clouding of consciousness, the development of a "cogwheel" rigidity in the extremities, there could be uncontrollable grasping and sucking reflexes all of a sudden, in some cases patient may enter a comatose state. Such physical and psychological symptoms normally affects people who are hospitalized and are being undergoing intravenous feeding on liquid foods that are without supplemented vitamins.

Niacin (vitamin B3) actively causes dilation in the blood vessels, leading to a temporary lowering of the blood pressure and appears to positively lower blood cholesterol levels when they are high. However, the use of niacin is surrounded by a certain amount of controversy especially regarding its supplemental use in the treatment of people affected by heart disease. The blockage of blood vessels is the primary problem in people affected by heart disease. There is a beneficial effect from any factor that results in the widening of the blood vessels and the restoration of circulation. The risk of developing heart disease is also heightened by elevated levels of blood cholesterol and persistent high blood pressure. Thus there is potential benefit for any single factor that can lower the blood pressure or lead to the reduction in total cholesterol levels.

At least theoretically, people with heart disease seem to be benefited by supplements of niacin. An abnormal electrocardiogram seems evident in most victims suffering from pellagra - this indicates that they suffer from an abnormal functioning of the heart. When such deficiencies are treated using niacin supplements, these abnormalities start to disappear by themselves and the person recovers from the deficiency.

People who have very bad dietary habits are prone to suffer from a niacin deficiency. Individuals who are also susceptible to a niacin deficiency include people who consume low-calorie and low-protein, or high-fat and carbohydrate rich diets for long periods of time. Susceptible individuals include alcoholics and people affected by diseases that interfere with the proper digestion and absorption of food - this category of individuals at risk includes those who suffer from any form of chronic diarrhea, those affected by liver cirrhosis and those who are affected by tuberculosis. Individuals deficient in levels of pyridoxine (vitamin B6), which is essential to the bio-chemical conversion of the amino acid tryptophan to niacin, may suffer from a deficiency of niacin as a secondary effect. Individuals affected by Hartnup's disease have an increased metabolic requirement for niacin to prevent the development of pellagra; this inherited disease is marked by a defect in the bio-chemical conversion of tryptophan to niacin.

Niacin (vitamin B3) comes in two basic bio-chemical forms called niacinamide and nicotinic acid - simply known as niacin in day to day use. Niacinamide is the form of the vitamin commonly met with in the body of animals, while niacin tends to be sourced from plants. Niacin is rapidly converted into the niacinamide for inside the human body. The chemical form niacinamide is similar to niacin in all parameters and performs similar functions in the human body, with the exception that it does not induce vasodilation or the niacin flush in the person using the vitamin.

A large variety of supplemental doses of both niacin and niacinamide are available in the market, these dosages range from a few milligrams to 1000 milligram tablets or capsules.

Niacin is found in abundance in natural form from organ meats, yeast and fish, nuts and whole grains, leguminous plant foods like dried peas and beans. The amino acid tryptophan is found in large amounts in corn, niacin can be synthesized from this amino acid by the body, and however, the tryptophan found in corn is chemically "bound" and cannot be utilized by humans. Corn is subjected to alkali treatment for the kernels to release the tryptophan, which is then used in various proteins as well as in the synthesis of niacin. Substantial losses of niacin occur during the process of cooking or boiling foods as the vitamin is soluble in hot water - there is no way to prevent this loss, though it is a good idea to eat natural foods in a raw state to get at the vitamins.

Western societies of today are largely free of pellagra, the main disease induced by a deficiency of vitamin B3. Generalized physical symptoms induced by pellagra can include the complete loss of appetite, a persistent skin rash, prolonged diarrhea, changes in the mental state of the person, the development of a beefy tongue and problems with digestion as well as severe emotional disturbance leading to psychologically altered states of mind.

Usual dosage

Niacin as a RDA that ranges in amount from 6 mg for babies to 13 mg for most adult women and about 18 mg for the average man and all lactating women. The physiological effects of a deficiency can only be corrected by supplementing with many times these amounts of niacin, as one of the persistent effects of a niacin deficiency is a general lowering in the functioning of the gastrointestinal tract. Niacin supplements benefit some mentally ill people; these individuals who benefit from niacin therapy where the vitamin is given in the mega dose range are very likely to be suffering from metabolic deficiencies induced by defects present in certain enzyme systems which need niacin as a part of some bio-chemical pathway. The enzyme reactions are effectively forced to function by the very large doses of niacin given during a high dosage supplemental regimen. The use of niacin in treating heart disease is not similar and the vitamin's role in case of cardiac problems is different to the role it performs when it is supplemented. The effect induced by niacin in treating heart disease is a "pharmaceutical" or "medicational" effect, where the large doses of the vitamin in the body force a reaction to occur - this effect is desirable at all time but does not occur under normal circumstances. Dosages of niacin at thousands of milligrams per dose are common when treating these disorders.

Side effects and cautions

There is almost no safety issue regarding the supplement use of niacinamide, however, some people have experienced in rare cases physical symptoms affecting the liver, when the vitamin is taken at doses that exceed 1,000 mg of the vitamin daily. Physical symptoms such as flushing of the face, persistent headache and a bad stomach pain is also seen in some people who used niacin supplements in amounts that were as low as 50 - 100 mg a day. To correct some kinds of health disorders, certain doctors at times prescribe very high doses of niacin - some doses can even exceed 3,000 mg daily or more. Physical symptoms such as liver damage, diseases like diabetes, gastritis, damage to the eyes and even elevation in blood levels of uric acid are induced by high doses of niacin - uric acid accumulation in the body causes the diseased state called gout, and niacin must never be used in very high doses without first consulting a nutritionally oriented doctor about the risk of high doses and its effects on uric acid metabolism.

While no side effects are connected to the use of the inositol hexaniacinate form of niacin, the number of research projects that have been carried out in studying the safety of this form of the vitamin remains low and more clinical studies will shed a light on any safety issue concerning the use of this vitamin. The use of this form of niacin supplement in large amounts by some people - who often take in excess of several thousand milligrams daily - must be monitored and studied by a nutritionally oriented doctor to assess the safety of such high dosages.

The release of energy from metabolized carbohydrates is carried out by the vitamin B3 in conjunction with the vitamins B1 and B2. While many people use the niacin or niacinamide alone when supplementing, these vitamins are often and best taken together in the form of a B-complex or multi-vitamin supplement.


From Skip Van Lenten - Mar-30-2013
I began studying the effects of niacin and niacinamide on schizophrenic adolescents back in the early 70's. I became very familiar with Hoffer and Osmond's work, and corresponded with Dr. Hoffer before he passed away. I noticed that no one has mentioned vitamin C in these comments. Hoffer and Osmond always recommended an equal amount of vitamin C and niacin or niacinamide. Their original formula for treating schizophrenics, first published in 1951, was 1000 mg niacin (or niacinamide), 1000 mg of vitamin C, 100 mg of vitamin B1, 100 mg of vitamin B6, and 200 IU's of vitamin E, 3 x day.
From Joe Wheeler - Feb-16-2013
I have taken mega doses of niacin for years, prescribed originally by Dr. Abram Hoffer until he died. In the case of taking over 1,000 mg of niacin (1 gr) per day, niacin has one negative effect, the production of an unnatural form of cysteine called homocysteine (particularly harmful to the CV system). To negate this Dr. Hoffer also prescribed B6, folic acid (25 mg/day) and 1,000 mcg of B12 injected under the skin (subcutaneously), which one can learn to do oneself.
From Janet C - Feb-04-2013
After feeling like a guinea pig for years from trying different anti-depressants as suggested by doctors, I decided to wean myself off of the latest one my doctor prescribed, Lexapro. I gave it a good chance, but after 4 months, all it seemed to do was make me gain weight.
For several years, I've been ordering vitamins and supplements from a company that has quality products at a good price. After studying the work of Dr. Abram Hoffer, I decided to order some niacin in 500 mg tablets, along with my regular products. I took one, experienced the "flush" immediately, itched like crazy on my arms and had some nausea - not so good, probably should have started with a smaller amount. But since the doses for depression were so high, i.e., 9,000 mg per day, I took another tablet the next day. All that happened was the "flushing" which is not unpleasant, some slight itching and no nausea. Over a period of a few weeks, I am up to 3,000 mg per day. The "flush" still happens, but only lasts a few minutes. My neck, chest, head, and arms feel tingly and turn slightly pink.
Since it is a water soluble vitamin, it seems to be less dangerous than antidepressants. I take it 2 or 3 times a day, the last just before bed. It helps me sleep and seems to be giving me a decrease in depression. It's a little early to tell for sure. I'm going to stay at 3,000 mg a day, at least for now. I'll talk with my doctor again after I'm all weaned off the Lexapro and before I decide to up the dosage of niacin.
My cholesterol levels are on the upper end, but within normal range. I'm curious to see the results of the next blood test for that. I'm mainly trying it as an antidepressant.
From Niacin - Feb-27-2012
I have been taking niacin for a month now. I have bad migraines and when I take 1000 mg of niacin, the headache is gone that fast. I was just trying to cure my mental illness. I didn't know it was going to get rid of my migraines.
From DJ - Aug-01-2011
Based upon the writings of Abram Hoffer and Andrew Saul, I've been taking 4,000 mg of niacin daily for about six months now. I take 1000 mg with each meal and 1000 at bed time. My cholesterol dropped from 201 to 161 in 4 months and my mood has improved to where I feel cheerful all the time. You do need to gradually increase your dosage of niacin to minimize the flush. Abram Hoffer offers good suggestions for how to do this.
From WG - 2010
I have been taking niacin for close to a year now. I am taking it in 500 milligram doses, usually just one but sometimes two a day. It helps me with arthritic pain, sleep, and energy unless I take too much, which makes me jittery. In my opinion this powerful and unusually helpful vitamin is nevertheless just a helper. It does not work any miracles for me. So there is no substitute for eating the best we can (fat free, all raw, vegetarianism), getting enough sleep, and being a God fearing, Christ honouring, morally sound individual. Nothing ever can take the place of being truly honest in our holistic approach to health, and living a life holy unto the Lord.
From JP - 2010
I am a part of the Juvenon "Century" Club and, based upon advice in their "Ask the Experts" column, started taking 1000 mg of time-release niacin daily; I have a history of borderline high cholesterol. Recently, my company offered a non-fasting test for cholesterol which I took; to my absolute astonishment, my total cholesterol (which, last year was tested to be 240) had been reduced to 140 ... TOTAL. I believe that, not only has my body tolerated the dosage level, but the action of this supplement within my body has had a tremendous effect on my cholesterol rating. Parenthetically, I am a consistent, relentless exerciser and I do believe that this combination has resulted in these fabulous numbers. I am 62 years of age as of this writing. Hope that this is informative.
From JP - 2010
I have friends in their mid forty's who advocate using over 1,000 mg of niacin everyday. From what they have described, the effects of niacin over a several month period are astounding. The woman originally had poor eyesight, and over a half a year of daily niacin intake, no longer needs glasses. The man was over weight and now is fit and tone as if he were working out daily (which he is not). I have personally just begun trying out niacin and already I can feel my energy level increase. It may be weird to some, but I really enjoy the burning flush sensation.
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